Triazol-1-yl Benzamides Promote Anticoagulant Activity via Inhibition of Factor XIIa.

ABSTRACT:

Background

Human factor XIIa (FXIIa) is a plasma serine protease that plays a significant role in several physiological and pathological processes. Animal models have revealed an important contribution of FXIIa to thromboembolic diseases. Remarkably, animals and patients with FXII deficiency appear to have normal hemostasis. Thus, FXIIa inhibition may serve as a promising therapeutic strategy to attain safer and more effective anticoagulation. Very few small molecule inhibitors of FXIIa have been reported. We synthesized and investigated a focused library of triazol-1-yl benzamide derivatives for FXIIa inhibition.

Methods

We chemically synthesized, characterized, and investigated a focused library of triazol- 1-yl benzamide derivatives for FXIIa inhibition. Using a standardi

SUBMITTER: Al-Horani RA 

PROVIDER: S-EPMC10249145 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature