Pharmacotherapy treatment patterns at hospital discharge and clinical outcomes among patients with heart failure with reduced ejection fraction

ABSTRACT: Abstract

Background

This study aimed to assess the prescribing patterns of evidence‐based pharmacotherapy and their association with clinical outcomes in patients with heart failure with reduced ejection fraction (HFrEF) in Thailand.

Methods

A retrospective cohort study of patients with HFrEF was conducted. Treatment with a β‐blocker and renin–angiotensin system inhibitors (RASIs) with or without mineralocorticoid receptor antagonists (MRAs) at discharge was regarded as guideline‐directed medical therapy (GDMT). All others were considered non‐GDMT. The primary endpoint was the composite of all‐cause mortality or heart failure (HF) rehospitalization. Inverse‐probability‐treatment‐weighted adjusted Cox proportional hazard models were used to examine the treatment effects. <

SUBMITTER: Wongsalap Y 

PROVIDER: S-EPMC10249177 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature