Identification of colorectal cancer progression-associated intestinal microbiome and predictive signature construction.

ABSTRACT:

Objective

The relationship between intestinal microbiome and colorectal cancer (CRC) progression is unclear. This study aims to identify the intestinal microbiome associated with CRC progression and construct predictive labels to support the accurate assessment and treatment of CRC.

Method

The 192 patients included in the study were divided into stage I-II and stage III-IV CRC patients according to the pathological stages, and preoperative stools were collected from both groups for 16S rDNA sequencing of the intestinal microbiota. Pearson correlation and Spearman correlation coefficient analysis were used to analyze the differential intestinal microbiome and the correlation with tumor microenvironment and to predict the functional pathway. XGBoost model (XGB) and Random Fore

SUBMITTER: Liu J 

PROVIDER: S-EPMC10249256 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature