Prediction model for day 3 embryo implantation potential based on metabolites in spent embryo culture medium.

ABSTRACT:

Background

Metabolites in spent embryo culture medium correlate with the embryo's viability. However, there is no widely accepted method using metabolite dada to predict successful implantation. We sought to combine metabolomic profiling of spent embryo culture medium and clinical variables to create an implantation prediction model as an adjunct to morphological screening of day 3 embryos.

Methods

This investigation was a prospective, nested case-control study. Forty-two day 3 embryos from 34 patients were transferred, and the spent embryo culture medium was collected. Twenty-two embryos implanted successfully, and the others failed. Metabolites in the medium relevant to implantation were detected and measured by Liquid Chromatography-Mass Spectrometry. Clinical signatures

SUBMITTER: Liang R 

PROVIDER: S-EPMC10249307 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature