Highly Attenuated Poxvirus-Based Vaccines Against Emerging Viral Diseases.

ABSTRACT: Although one member of the poxvirus family, variola virus, has caused one of the most devastating human infections worldwide, smallpox, the knowledge gained over the last 30 years on the molecular, virological and immunological mechanisms of these viruses has allowed the use of members of this family as vectors for the generation of recombinant vaccines against numerous pathogens. In this review, we cover different aspects of the history and biology of poxviruses with emphasis on their application as vaccines, from first- to fourth-generation, against smallpox, monkeypox, emerging viral diseases highlighted by the World Health Organization (COVID-19, Crimean-Congo haemorrhagic fever, Ebola and Marburg virus diseases, Lassa fever, Middle East respiratory syndrome and severe acute respirator

SUBMITTER: Perdiguero B 

PROVIDER: S-EPMC10249371 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature