Altered gut microbiota profile in patients with perimenopausal panic disorder.

ABSTRACT:

Introduction

Females in the perimenopausal period are susceptible to mood disorders. Perimenopausal panic disorder (PPD) is characterized by repeated and unpredictable panic attacks during perimenopause, and it impacts the patient's physical and mental health and social function. Pharmacotherapy is limited in the clinic, and its pathological mechanism is unclear. Recent studies have demonstrated that gut microbiota is strongly linked to emotion; however, the relation between PPD and microbiota is limitedly known.

Methods

This study aimed to discover specific microbiota in PPD patients and the intrinsic connection between them. Gut microbiota was analyzed in PPD patients (n = 40) and healthy controls (n = 40) by 16S rRNA sequencing.

Results

The results sh

SUBMITTER: Lin S 

PROVIDER: S-EPMC10249373 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature