Genes with specificity for expression in the round cell layer of the growth plate are enriched in genomewide association study (GWAS) of human height.

ABSTRACT: Human adult height reflects the outcome of childhood skeletal growth. Growth plate (epiphyseal) chondrocytes are key determinants of height. As epiphyseal chondrocytes mature and proliferate, they pass through three developmental stages, which are organized into three distinct layers in the growth plate: (i) resting (round), (ii) proliferative (flat), and (iii) hypertrophic. Recent genomewide association studies (GWASs) of human height identified numerous associated loci, which are enriched for genes expressed in growth plate chondrocytes. However, it remains unclear which specific genes expressed in which layers of the growth plate regulate skeletal growth and human height. To connect the genetics of height and growth plate biology, we analyzed GWAS data through the lens of gene expressio

SUBMITTER: Renthal NE 

PROVIDER: S-EPMC10249375 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature