A Perfluorocarbon-Coated ZrP Cation Exchanger with Excellent Ammonium Selectivity and Chemical Stability: An Oral Sorbent for End-Stage Kidney Disease (ESKD).

ABSTRACT: An oral sorbent to remove NH₄⁺ within the small intestine of end-stage kidney disease (ESKD) patients could reduce blood urea levels and diminish their dialysis treatment burden. But current sorbent materials like amorphous zirconium phosphate particles Zr(HPO₄)₂·H₂O (ZrP) lack the selectivity to remove NH₄⁺ in water solution with other competing ions. Our previous work found that a gas-permeable, hydrophobic polydimethylsiloxane (PDMS) coating on ZrP improved the material's selectivity for NH₄⁺. However, a competing ion Ca²⁺ was still removed by PDMS-coated ZrP sorbent, and the permeability of the PDMS coating to Ca²⁺ was increased after low-pH stomach-like condition ex

SUBMITTER: Richards E 

PROVIDER: S-EPMC10249412 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature