KRAS Mutation Variants and Co-occurring PI3K Pathway Alterations Impact Survival for Patients with Pancreatic Ductal Adenocarcinomas.

ABSTRACT:

Background

KRAS variant alleles may have differential biological properties which impact prognosis and therapeutic options in pancreatic ductal adenocarcinomas (PDA).

Materials and methods

We retrospectively identified patients with advanced PDA who received first-line therapy and underwent blood and/or tumor genomic sequencing at the University of Washington between 2013 and 2020. We examined the incidence of KRAS mutation variants with and without co-occurring PI3K or other genomic alterations and evaluated the association of these mutations with clinicopathological characteristics and survival using a Cox proportional hazards model.

Results

One hundred twenty-six patients had genomic sequencing data; KRAS mutations were identified in 111 PDA and included the follow

SUBMITTER: Diehl AC 

PROVIDER: S-EPMC10249424 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature