Ferroptosis-associated gene CISD2 suppresses colon cancer development by regulating tumor immune microenvironment.

ABSTRACT:

Background

Despite the association of ferroptosis with various tumors, the specific mechanism by which it influences colon adenocarcinoma (COAD) microenvironmental equilibrium remains elusive. This study aims to elucidate how ferroptosis affects COAD microenvironmental homeostasis and its potential impact on COAD research.

Objective

By employing genetic screening and single-cell analysis of tumor data, we investigated the role of ferroptosis genes in COAD microenvironmental homeostasis. The genes were correlated with immune cell infiltration in tissue samples and patient outcomes.

Methods

Ferroptosis-associated genes were initially identified through the FerrDb database. Utilizing the tidyverse and Seurat packages, genes with substantial expression differences were ex

SUBMITTER: Xu Y 

PROVIDER: S-EPMC10249621 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature