Reduced structural connectivity of the medial temporal lobe including the perforant path is associated with aging and verbal memory impairment.

ABSTRACT: The perforant path, the white matter bundle connecting the entorhinal cortex (ERC) with the hippocampal formation deteriorates with age-related cognitive decline. Previous investigations using diffusion-weighted MRI to quantify perforant path integrity in-vivo have been limited due to image resolution or have quantified the perforant path using methods susceptible to partial volume effects such as the tensor model and without consideration of its 3-dimensional morphology. In this investigation, we use quantitative-anisotropy informed tractography derived from ultra-high resolution diffusion imaging (ZOOMit) to investigate structural connectivity of the perforant path and other medial temporal lobe (MTL) pathways in older adults (63 to 98 years old, n = 51). We show that graph density withi

SUBMITTER: Granger SJ 

PROVIDER: S-EPMC10249650 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature