Capillary driven microfluidic sequential flow device for point-of-need ELISA: COVID-19 serology testing.

ABSTRACT: A capillary-driven microfluidic sequential flow device, designed for eventual at-home or doctor's office use, was developed to perform an enzyme-linked immunosorbent assay (ELISA) for serology assays. Serology assays that detect SARS-CoV-2 antibodies can be used to determine prior infection, immunity status, and/or individual vaccination status and are typically run using well-plate ELISAs in centralized laboratories, but in this format SARs-CoV-2 serology tests are too expensive and/or slow for most situations. Instead, a point-of-need device that can be used at home or in doctor's offices for COVID-19 serology testing would provide critical information for managing infections and determining immune status. Lateral flow assays are common and easy to use, but lack the sensitivity needed to

SUBMITTER: Carrell C 

PROVIDER: S-EPMC10249653 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature