Patterned cPCDH expression regulates the fine organization of the neocortex.

ABSTRACT: The neocortex consists of a vast number of diverse neurons that form distinct layers and intricate circuits at the single-cell resolution to support complex brain functions¹. Diverse cell-surface molecules are thought to be key for defining neuronal identity, and they mediate interneuronal interactions for structural and functional organization^2-6. However, the precise mechanisms that control the fine neuronal organization of the neocortex remain largely unclear. Here, by integrating in-depth single-cell RNA-sequencing analysis, progenitor lineage labelling and mosaic functional analysis, we report that the diverse yet patterned expression of clustered protocadherins (cPCDHs)-the largest subgroup of the cadherin superfamily of cell-adhesion molecules⁷-regul

SUBMITTER: Lv X 

PROVIDER: S-EPMC10249668 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature