MicroRNA 9 Is a Regulator of Endothelial to Mesenchymal Transition in Diabetic Retinopathy.

ABSTRACT:

Purpose

Diabetic retinopathy (DR) is a significant cause of blindness. Most research around DR focus on late-stage developments rather than early changes such as early endothelial dysfunction. Endothelial-to-mesenchymal transition (EndMT), an epigenetically regulated process whereby endothelial cells lose endothelial characteristics and adopt mesenchymal-like phenotypes, contributes to early endothelial changes in DR. The epigenetic regulator microRNA 9 (miR-9) is suppressed in the eyes during DR. MiR-9 plays a role in various diseases and regulates EndMT-related processes in other organs. We investigated the role miR-9 plays in glucose-induced EndMT in DR.

Methods

We examined the effects of glucose on miR-9 and EndMT using human retinal endothelial cells (HRECs). We then us

SUBMITTER: Wang E 

PROVIDER: S-EPMC10249683 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature