Association between pseudoexfoliation and Alzheimer's disease-related brain atrophy.

ABSTRACT:

Background/aims

Pseudoexfoliation (PEX) syndrome is an age-related disorder characterized by the accumulation of extracellular material in the anterior eye segment. PEX pathogenesis is not fully understood, but amyloid which accumulates in the brain of patients with Alzheimer's disease (AD) is a PEX component. PEX deposition shares features with amyloid aggregation in AD, and brain atrophy is a common AD feature, with β-amyloid accumulation among contributing factors. This study investigated whether PEX syndrome is associated with AD-related brain atrophy.

Methods

We reviewed the medical records of patients diagnosed with PEX at the Veterans Health Service Medical Center between January 2015 and August 2021. This retrospective cohort study included 48 patients with PEX and 4

SUBMITTER: Jeong WC 

PROVIDER: S-EPMC10249790 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature