Melatonin alleviates lung injury in H1N1-infected mice by mast cell inactivation and cytokine storm suppression.

ABSTRACT: Influenza A virus (IAV) H1N1 infection is a constant threat to human health and it remains so due to the lack of an effective treatment. Since melatonin is a potent antioxidant and anti-inflammatory molecule with anti-viral action, in the present study we used melatonin to protect against H1N1 infection under in vitro and in vivo conditions. The death rate of the H1N1-infected mice was negatively associated with the nose and lung tissue local melatonin levels but not with serum melatonin concentrations. The H1N1-infected AANAT-/- melatonin-deficient mice had a significantly higher death rate than that of the WT mice and melatonin administration significantly reduced the death rate. All evidence confirmed the protective effects of melatonin against H1N1 infection. Further study identified t

SUBMITTER: Huo C 

PROVIDER: S-EPMC10249807 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature