Changes in Spina Bifida Lesion Level after Folic Acid Fortification in the US.

ABSTRACT:

Objective

To assess whether the severity of cases of spina bifida changed after the institution of mandatory folic acid fortification in the US.

Study design

Six active population-based birth defects programs provided data on cases of spina bifida for 1992-1996 (prefortification period) and 1999-2016 (postfortification period). The programs contributed varying years of data. Case information included both a medical record verbatim text description of the spina bifida diagnosis and spina bifida codes (International Classification of Diseases, Clinical Modification, or a modified birth defects surveillance coding system). Comparing the prefortification and postfortification periods, aORs for case severity (upper-level lesions [cervical, thoracic] vs lower-level lesions [lumbar

SUBMITTER: Mai CT 

PROVIDER: S-EPMC10250025 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature