Classifying the unclassifiable-a Delphi study to reach consensus on the fibrotic nature of diseases.

ABSTRACT:

Background

Traditionally, clinical research has focused on individual fibrotic diseases or fibrosis in a particular organ. However, it is possible for people to have multiple fibrotic diseases. While multi-organ fibrosis may suggest shared pathogenic mechanisms, yet there is no consensus on what constitutes a fibrotic disease and therefore fibrotic multimorbidity.

Aim

A Delphi study was performed to reach consensus on which diseases may be described as fibrotic.

Methods

Participants were asked to rate a list of diseases, sub-grouped according to eight body regions, as 'fibrotic manifestation always present', 'can develop fibrotic manifestations', 'associated with fibrotic manifestations' or 'not fibrotic nor associated'. Classifications of 'fibrotic manifestation alwa

SUBMITTER: Massen GM 

PROVIDER: S-EPMC10250078 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature