A modified Child-Turcotte-Pugh score based on plasma ammonia predicts survival for patients with decompensated cirrhosis.

ABSTRACT:

Background

Plasma ammonia has been shown to be an independent prognostic factor for patients with liver cirrhosis.

Aim

We aimed to investigate the discrimination and calibration of a new prognostic model (aCTP) based on plasma ammonia (Amm) replacing hepatic encephalopathy (HE) in the Child-Turcotte-Pugh (CTP) score.

Design

Diagnostic test, paired design.

Methods

Baseline Amm levels were corrected to the upper limit of normal (Amm-ULN). We designed the new model based on the cut-off value of Amm-ULN in the observational cohort of 554 clinically stable cirrhotic patients from January 2012 to July 2019. External validation was carried out using prospective data from 185 patients with liver cirrhosis.

Results

Our analysis showed that each 1-point increase i

SUBMITTER: Wang X 

PROVIDER: S-EPMC10250080 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature