MultiNEP: a multi-omics network enhancement framework for prioritizing disease genes and metabolites simultaneously.

ABSTRACT:

Motivation

Many studies have successfully used network information to prioritize candidate omics profiles associated with diseases. The metabolome, as the link between genotypes and phenotypes, has accumulated growing attention. Using a "multi-omics" network constructed with a gene-gene network, a metabolite-metabolite network, and a gene-metabolite network to simultaneously prioritize candidate disease-associated metabolites and gene expressions could further utilize gene-metabolite interactions that are not used when prioritizing them separately. However, the number of metabolites is usually 100 times fewer than that of genes. Without accounting for this imbalance issue, we cannot effectively use gene-metabolite interactions when simultaneously prioritizing disease-associated met

SUBMITTER: Xu Z 

PROVIDER: S-EPMC10250081 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature