Optimisation of scan duration and image quality in oncological ⁸⁹Zr immunoPET imaging using the Biograph Vision PET/CT.

ABSTRACT:

Purpose

Monoclonal antibody (mAb)-based PET (immunoPET) imaging can characterise tumour lesions non-invasively. It may be a valuable tool to determine which patients may benefit from treatment with a specific monoclonal antibody (mAb) and evaluate treatment response. For ⁸⁹Zr immunoPET imaging, higher sensitivity of state-of-the art PET/CT systems equipped with silicon photomultiplier (SiPM)-based detector elements may be beneficial as the low positron abundance of ⁸⁹Zr causes a low signal-to-noise level. Moreover, the long physical half-life limits the amount of activity that can be administered to the patients leading to poor image quality even when using long scan durations. Here, we investigated the difference in semiquantitative performance between the PM

SUBMITTER: van Sluis J 

PROVIDER: S-EPMC10250429 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature