Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction.

ABSTRACT: Sodium (Na+) current is responsible for the rapid depolarization of cardiac myocytes that triggers the cardiac action potential upstroke. Recent studies have illustrated the presence of multiple pools of Na+ channels with distinct biophysical properties and subcellular localization, including clustering of channels at the intercalated disk and along the lateral membrane. Computational studies predict that Na+ channel clusters at the intercalated disk can regulate cardiac conduction via modulation of the narrow intercellular cleft between electrically coupled myocytes. However, these studies have primarily focused on the redistribution of Na+ channels between intercalated disk and lateral membranes and have not considered the distinct biophysical properties of the Na+ channel subpopulations

SUBMITTER: Weinberg SH 

PROVIDER: S-EPMC10250552 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature