Influences of resting-state intrinsic functional brain connectivity on the antidepressant treatment response in late-life depression.

ABSTRACT:

Background

Late-life depression (LLD) is characterized by differences in resting state functional connectivity within and between intrinsic functional networks. This study examined whether clinical improvement to antidepressant medications is associated with pre-randomization functional connectivity in intrinsic brain networks.

Methods

Participants were 95 elders aged 60 years or older with major depressive disorder. After clinical assessments and baseline MRI, participants were randomized to escitalopram or placebo with a two-to-one allocation for 8 weeks. Non-remitting participants subsequently entered an 8-week trial of open-label bupropion. The main clinical outcome was depression severity measured by MADRS. Resting state functional connectivity was measured between a

SUBMITTER: Ahmed R 

PROVIDER: S-EPMC10250562 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature