Immune response plays a role in Mycoplasma pneumoniae pneumonia.

ABSTRACT:

Introduction

Mycoplasma pneumoniae (MP) is a major pathogen of community-acquired pneumonia in children. However, the specific pathogenesis of the progression of Mycoplasma pneumoniae pneumonia (MPP) is unclear. We aimed to reveal the landscape of microbiota and the host immune response in MPP.

Methods

This self-controlled study analyzed the microbiome and transcriptome of bronchoalveolar lavage fluid (BALF) from the severe side (SD) and opposite side (OD) of 41 children with MPP from January to December 2021 and revealed the differences of the peripheral blood neutrophil function among children with mild MPP, severe MPP, and healthy children through transcriptome sequencing.

Results

The MP load or the pulmonary microbiota had no significant difference between the SD

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC10250694 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature