Two-sample Mendelian randomization analysis evaluates causal associations between inflammatory bowel disease and osteoporosis.

ABSTRACT:

Introduction

Over the past few years, multiple observational studies have speculated a potential association between inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn's disease (CD), and osteoporosis. However, no consensus has been reached regarding their interdependence and pathogenesis. Herein, we sought to further explore the causal associations between them.

Methods

We validated the association between IBD and reduced bone mineral density in humans based on genome-wide association studies (GWAS) data. To investigate the causal relationship between IBD and osteoporosis, we performed a two-sample Mendelian randomization study using training and validation sets. Genetic variation data for IBD, CD, UC, and osteoporosis were derived from publi

SUBMITTER: Dai Z 

PROVIDER: S-EPMC10250718 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature