Genome-wide detection of m6A-associated SNPs in atrial fibrillation pathogenesis.

ABSTRACT:

Objective

N6-Methyladenosine (m6A) modification is of great importance in both the pathological conditions and physiological process. The m6A single nucleotide polymorphisms (SNPs) are associated with cardiovascular diseases including coronary artery disease, heart failure. However, it is unclear whether m6A-SNPs are involved in atrial fibrillation (AF). Here, we aimed to explore the relationship between m6A-SNPs and AF.

Method

The relationship between m6A-SNPs and AF was evaluated by analyzing the AF genome-wide association study (GWAS) and m6A-SNPs annotated by the m6AVar database. Further, eQTL and gene differential expression analysis were performed to confirm the association between these identified m6A-SNPs and their target genes in the development of AF. Moreover, we

SUBMITTER: Huang Y 

PROVIDER: S-EPMC10250744 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature