Narrow funnel-like interaction energy distribution is an indicator of specific protein interaction partner.

ABSTRACT: Protein interaction networks underlie countless biological mechanisms. However, most protein interaction predictions are based on biological evidence that are biased to well-known protein interaction or physical evidence that exhibits low accuracy for weak interactions and requires high computational power. In this study, a novel method has been suggested to predict protein interaction partners by investigating narrow funnel-like interaction energy distribution. In this study, it was demonstrated that various protein interactions including kinases and E3 ubiquitin ligases have narrow funnel-like interaction energy distribution. To analyze protein interaction distribution, modified scores of iRMS and TM-score are introduced. Then, using these scores, algorithm and deep learning model for pr

SUBMITTER: Choi J 

PROVIDER: S-EPMC10250834 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature