Enhancing de novo ceramide synthesis induced by bisphenol A exposure aggravates metabolic derangement during obesity.

ABSTRACT:

Objective

Exposure to bisphenol A (BPA) has been shown to increase the prevalence of obesity and its related insulin resistance (IR). Ceramide is a sphingolipid known to facilitate the production of proinflammatory cytokines and subsequently exacerbate inflammation and IR during the progression of obesity. Here, we investigated the effects of BPA exposure on ceramide de novo synthesis and whether increased ceramides aggravate adipose tissue (AT) inflammation and obesity-related IR.

Methods

A population-based case-control study was conducted to explore the relationship between BPA exposure and IR and the potential role of ceramide in AT in obesity. Next, we used mice reared on a normal chow diet (NCD) or a high-fat diet (HFD) to verify the results from the population study an

SUBMITTER: Wang G 

PROVIDER: S-EPMC10250932 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature