SEC24D gene as a biomarker in human cancers and its association with CD8+ T cell immune cell infiltration.

ABSTRACT:

Objective

The SEC24D (SEC24 Homolog D, COPII Coat Complex Component) gene belongs to the SEC24 subfamily of genes. The protein encoded by this gene, along with its other binding partners, mediates the transport of newly-synthesized proteins from the endoplasmic reticulum to the Golgi apparatus.

Methods

A pan-cancer analysis of this gene, as well as its diagnostic and prognostic implications, are lacking in the medical literature. First, we analyzed SEC24D gene expression, its prognostic effect, promoter methylation level, genetic alteration landscape, pathways, CD8+ T immune cell infiltration, and gene-drug network in various types of cancer through various online databases and bioinformatic tools. Then, we performed the expression and methylation validation analysis of the

SUBMITTER: Sarwar S 

PROVIDER: S-EPMC10251021 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature