The Role of the Complement Pathway in Clinical Progression of Geographic Atrophy: Analysis of the Phase III Chroma and Spectri Trials.

ABSTRACT:

Purpose

To investigate the relationship between complement pathway activities and progression of geographic atrophy (GA) secondary to age-related macular degeneration in samples collected from patients enrolled in the Chroma and Spectri trials.

Design

Chroma and Spectri were phase III, double-masked, and sham-controlled, 96-week trials.

Participants

Aqueous humor (AH) samples collected at baseline and week 24 visits from 81 patients with bilateral GA across all 3 treatment groups (intravitreal lampalizumab 10 mg every 6 weeks, every 4 weeks, or corresponding sham procedures) were tested, along with patient-matched plasma samples collected at baseline.

Methods

Antibody capture assays using the Simoa platform were used to measure the levels of complement factor B

SUBMITTER: Edmonds R 

PROVIDER: S-EPMC10251071 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature