Bladder-sparing approaches for muscle invasive bladder cancer: a narrative review of current evidence and future perspectives.

ABSTRACT:

Background and objective

In recent years, the application of less-invasive "bladder-sparing" trimodal therapy (TMT) in selected muscle-invasive bladder cancer (MIBC) patients unfit for or who declined radical cystectomy (RC) has been increasing. This review aims to summarize the current evidence and future perspectives of bladder-sparing therapy for MIBC.

Methods

A non-systematic Medline/PubMed literature search was conducted on July 2022 with the following keywords 'MIBC', 'bladder-sparing', 'chemotherapy', 'radiotherapy', 'trimodal', 'multimodal', and 'immunotherapy'.

Key content and findings

All monotherapies are inferior to RC or combination therapy and should not be routinely used for curative intent. Radiotherapy (RT) alone has been shown to have poorer outcomes

SUBMITTER: Fan X 

PROVIDER: S-EPMC10251081 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature