Unknown

Dataset Information

0

Successful treatment of ejaculation pain with silodosin in patient with Zinner syndrome: a case report.


ABSTRACT:

Background

Zinner syndrome is a rare congenital anomaly featuring a unilateral seminal vesicle cyst and ipsilateral renal agenesis. While the majority of affected patients are asymptomatic and followed with conservative management, others have symptoms such as micturition, ejaculatory difficulties, and/or pain, thus may require treatment. These patients often undergo an invasive procedure as first-line treatment, such as transurethral resection of the ejaculatory duct, or aspiration and drainage, which reduces pressure within the seminal vesicle cyst, or surgical resection of the seminal vesicle. Reported here is a patient with ejaculation pain and pelvic discomfort associated with Zinner syndrome who was successfully treated in a non-invasive manner with silodosin, an α1-adrenoceptor antagonist.

Case description

A 37-year-old Japanese male had ejaculation pain and pelvic discomfort associated with Zinner syndrome. Two months of treatment with silodosin, an α1-blocker, resulted in complete pain relief. Thereafter, conservative management with regular follow-up examinations has been conducted for five years, without recurrence of ejaculation pain or other symptoms associated with Zinner syndrome.

Conclusions

This is the first known published case report of a patient with Zinner syndrome treated with silodosin who was completely relieved from ejaculation pain. The effect of α1-adrenoceptor antagonists to inhibit seminal vesicle contraction, as well as cause relaxation of smooth muscles of the urethra and prostate may contribute to reduce pain associated with ejaculation. We concluded that silodosin treatment should be attempted in affected patients before considering surgical treatment.

SUBMITTER: Uetani M 

PROVIDER: S-EPMC10251087 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Successful treatment of ejaculation pain with silodosin in patient with Zinner syndrome: a case report.

Uetani Masato M   Yamabe Fumito F   Hori Shunsuke S   Aoki Hiroshi H   Sakurabayashi Kei K   Okawa Mizuho M   Kobayashi Hideyuki H   Nakajima Koichi K   Nagao Koichi K   Mitsui Yozo Y  

Translational andrology and urology 20230504 5


<h4>Background</h4>Zinner syndrome is a rare congenital anomaly featuring a unilateral seminal vesicle cyst and ipsilateral renal agenesis. While the majority of affected patients are asymptomatic and followed with conservative management, others have symptoms such as micturition, ejaculatory difficulties, and/or pain, thus may require treatment. These patients often undergo an invasive procedure as first-line treatment, such as transurethral resection of the ejaculatory duct, or aspiration and  ...[more]

Similar Datasets

| S-EPMC9289330 | biostudies-literature
| S-EPMC11895205 | biostudies-literature
| S-EPMC9784601 | biostudies-literature
| S-EPMC10102822 | biostudies-literature
| S-EPMC11848090 | biostudies-literature
| S-EPMC6148829 | biostudies-literature
| S-EPMC11372941 | biostudies-literature
| S-EPMC9257249 | biostudies-literature
| S-EPMC10084611 | biostudies-literature
| S-EPMC11870976 | biostudies-literature