Fertility in patients with Hirschsprung's disease: population-based cohort study.

ABSTRACT:

Background

The aim of this study was to assess fertility in patients treated for Hirschsprung's disease.

Methods

This was a nationwide, population-based cohort study, including all patients with Hirschsprung's disease registered in the Swedish National Patient Register between 1964 and 2004. Five age- and sex-matched controls per patient were randomly selected by Statistics Sweden. Outcome data were retrieved from the Multi-Generation Register, and the Swedish National Patient Register. Study exposure was Hirschsprung's disease and the primary outcome was fertility, defined as having one or more children. Individuals with chromosomal anomalies were excluded.

Results

The study cohort comprised 597 patients with Hirschsprung's disease (143 female) and 2969 controls (714

SUBMITTER: Bystrom C 

PROVIDER: S-EPMC10251299 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature