Tryptophan-like side chain holding aptamers inhibit respiratory syncytial virus infection of lung epithelial cells.

ABSTRACT: Respiratory syncytial virus (RSV) is a leading cause of serious and even fatal acute lower respiratory tract infections in infants and in the elderly. Potent RSV neutralization has been achieved by antibodies that selectively bind the prefusion form of the viral fusion (F) protein. We hypothesised that similar potent neutralization could be achieved using F protein targeting aptamers. Aptamers have yet to reach their translational potential for therapeutics or diagnostics due to their short half-life and limited range of target-aptamer interactions; these shortcomings can, however, be ameliorated by application of amino acid-like side chain holding nucleotides. In this study, a stabilized version of the prefusion RSV F protein was targeted by aptamer selection using an oligonucleotide libr

SUBMITTER: Percze K 

PROVIDER: S-EPMC10251311 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature