Alterations in gene expression of recA and umuDC in antibiotic-resistant Acinetobacter baumannii.

ABSTRACT: Acinetobacter baumannii is a critical pathogen with an efficient SOS (Save Our Ship) system that plays a significant role in antibiotic resistance. This prospective descriptive study aimed to investigate the association between expression levels of recA and umuDC genes, which are critical in SOS pathways, and antibiotic resistance in A. baumannii. We analyzed 78 clinical isolates and 31 ecological isolates using the Vitek-2 system for bacterial identification and antibiotic susceptibility testing and confirmed molecular identification of A. baumannii by conventional PCR of bla_OXA-51 and bla_OXA-23. Quantitative real-time polymerase chain reaction was used to determine gene expression levels of recA and umuDC. The results

SUBMITTER: Ameer NAA 

PROVIDER: S-EPMC10251391 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature