Real-world use of bone modifying agents in metastatic, castration-resistant prostate cancer.

ABSTRACT:

Background

Bone modifying agents (BMAs) prevent skeletal related events among patients with metastatic, castration-resistant prostate cancer (mCRPC) involving bone and prevent osteoporotic fractures among patients at high risk. BMA utilization for patients with mCRPC has not been well quantified.

Methods

We used linked SEER registry and Medicare claims data. We included men diagnosed with stage IV prostate adenocarcinoma during 2007-2015, aged > = 66 at diagnosis, with sufficient continuous enrollment in Medicare Parts A, B, and D, who received androgen deprivation therapy. We limited to those who subsequently received a CRPC-defining treatment (CDT). We identified patients with evidence of bone metastasis using claims. Our primary outcome was receipt of a BMA (zoledronic ac

SUBMITTER: Mitchell AP 

PROVIDER: S-EPMC10251421 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature