Collaborative cross strain CC011/UncJ as a novel mouse model of T2-high, severe asthma.

ABSTRACT: Among asthmatics, there is significant heterogeneity in the clinical presentation and underlying pathophysiological mechanisms, leading to the recognition of multiple disease endotypes (e.g., T2-high vs. T2-low). This heterogeneity extends to severe asthmatics, who may struggle to control symptoms even with high-dose corticosteroid treatment and other therapies. However, there are limited mouse models available to model the spectrum of severe asthma endotypes. We sought to identify a new mouse model of severe asthma by first examining responses to chronic allergen exposure among strains from the Collaborative Cross (CC) mouse genetics reference population, which contains greater genetic diversity than other inbred strain panels previously used for models of asthma. Mice from five CC strain

SUBMITTER: Donoghue LJ 

PROVIDER: S-EPMC10251525 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature