Effect of propranolol and clonidine after severe traumatic brain injury: a pilot randomized clinical trial.

ABSTRACT:

Objective

To evaluate the safety, feasibility, and efficacy of combined adrenergic blockade with propranolol and clonidine in patients with severe traumatic brain injury (TBI).

Background

Administration of adrenergic blockade after severe TBI is common. To date, no prospective trial has rigorously evaluated this common therapy for benefit.

Methods

This phase II, single-center, double-blinded, pilot randomized placebo-controlled trial included patients aged 16-64 years with severe TBI (intracranial hemorrhage and Glasgow Coma Scale score ≤ 8) within 24 h of ICU admission. Patients received propranolol and clonidine or double placebo for 7 days. The primary outcome was ventilator-free days (VFDs) at 28 days. Secondary outcomes included catecholamine levels, hospital len

SUBMITTER: Nordness MF 

PROVIDER: S-EPMC10251526 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature