Therapeutic Potential of a Small-Molecule STAT3 Inhibitor in a Mouse Model of Colitis.

ABSTRACT:

Background and aims

Inflammatory bowel disease (IBD) predisposes to colorectal cancer (CRC). In the current studies, we used the dextran sodium sulfate (DSS) murine model of colitis, which is widely used in preclinical studies, to determine the contribution of STAT3 to IBD. STAT3 has two isoforms: (STAT3 α; which has pro-inflammatory and anti-apoptotic functions, and STAT3β; which attenuates the effects of STAT3α). In the current study, we determined the contribution of STAT3 to IBD across all tissues by examining DSS-induced colitis in mice that express only STAT3α and in mice treated with TTI-101, a direct small-molecule inhibitor of both isoforms of STAT3.

Methods

We examined mortality, weight loss, rectal bleeding, diarrhea, colon shortening, apoptosis of colonic CD4+ T-

SUBMITTER: Robinson P 

PROVIDER: S-EPMC10251885 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature