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Overview of Molecular Detection Technologies for MET in Lung Cancer.

ABSTRACT: MET tyrosine kinase receptor pathway activation has become an important actionable target in solid tumors. Aberrations in the MET proto-oncogene, including MET overexpression, the activation of MET mutations, MET mutations that lead to MET exon 14 skipping, MET gene amplifications, and MET fusions, are known to be primary and secondary oncogenic drivers in cancer; these aberrations have evolved as predictive biomarkers in clinical diagnostics. Thus, the detection of all known MET aberrations in daily clinical care is essential. In this review, current molecular technologies for the detection of the different MET aberrations are highlighted, including the benefits and drawbacks. In the future, another focus will be on the standardization of detection technologies for the delivery of reliable, quick, and affordable tests in clinical molecular diagnostics.

SUBMITTER: Heydt C

PROVIDER: S-EPMC10251963 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Overview of Molecular Detection Technologies for MET in Lung Cancer.

Heydt Carina C Ihle Michaela Angelika MA Merkelbach-Bruse Sabine S

Cancers 20230526 11

MET tyrosine kinase receptor pathway activation has become an important actionable target in solid tumors. Aberrations in the MET proto-oncogene, including MET overexpression, the activation of MET mutations, MET mutations that lead to MET exon 14 skipping, MET gene amplifications, and MET fusions, are known to be primary and secondary oncogenic drivers in cancer; these aberrations have evolved as predictive biomarkers in clinical diagnostics. Thus, the ...[more]

PMID: 37296895

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