Clinical Outcomes Depending on Sympathetic Innervation in Pancreatic Cancer.

ABSTRACT:

Background

The aim of our study was to evaluate sympathetic neuronal remodeling in patients with pancreatic cancer, together with its correlation with clinical outcomes.

Methods

In this descriptive, retrospective study, we analyzed pancreatic cancer specimens and peritumoral pancreatic tissue from 122 patients. We also investigated tyrosine hydroxylase immunoreactivity for the analysis of sympathetic nerve fibers and beta 2 adrenoreceptors immunoreactivity. To investigate the potential interaction between tyrosine hydroxylase (TH), beta 2 adrenoreceptors (B2A) immunoreactivity, and clinicopathological outcomes, we used the median to classify each case as TH+, respectively, B2A+ (if it presented a value higher than the median).

Results

Firstly, the overall survival was

SUBMITTER: Tartea EA 

PROVIDER: S-EPMC10252059 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature