Ontology highlight
ABSTRACT:
SUBMITTER: Ahmed EH
PROVIDER: S-EPMC10252287 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Ahmed Elshafa Hassan EH Lustberg Mark M Hale Claire C Sloan Shelby S Mao Charlene C Zhang Xiaoli X Ozer Hatice Gulcin HG Schlotter Sarah S Smith Porsha L PL Jeney Frankie F Chan Wing Keung WK Harrington Bonnie K BK Weigel Christoph C Brooks Eric E Klimaszewski Haley L HL Oakes Christopher C CC Abebe Tamrat T Ibrahim Muntaser E ME Alinari Lapo L Behbehani Gregory K GK Shindiapina Polina P Caligiuri Michael A MA Baiocchi Robert A RA
Cancers 20230603 11
Epstein-Barr virus (EBV) is a ubiquitous herpes virus associated with various cancers. EBV establishes latency with life-long persistence in memory B-cells and can reactivate lytic infection placing immunocompromised individuals at risk for EBV-driven lymphoproliferative disorders (EBV-LPD). Despite the ubiquity of EBV, only a small percentage of immunocompromised patients (~20%) develop EBV-LPD. Engraftment of immunodeficient mice with peripheral blood mononuclear cells (PBMCs) from healthy EBV ...[more]