Neutrophil extracellular trap burden correlates with the stenosis of coronary atherosclerosis.

ABSTRACT:

Background

Coronary atherosclerosis diseases (CADs) are associated with chronic inflammation. Neutrophil extracellular traps (NETs) are a type of novel proinflammatory cytokines whose levels are dramatically elevated in acute coronary syndrome. We conducted this study to further evaluate the association between circulating NET-associated markers and CAD in Chinese adults.

Methods

A total of 174 patients with CAD and 55 healthy controls were screened using percutaneous coronary intervention or coronary computed tomography angiography. Blood lipid levels, blood glucose levels, and blood cell counts were determined using commercial kits. Serum levels of myeloperoxidase (MPO) and neutrophil elastase (NE) were measured using ELISA. Double-stranded DNA (dsDNA) in serum was quantif

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10252804 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature