Conformation-Specific Association of Prion Protein Amyloid Aggregates with Tau Protein Monomers.

ABSTRACT: Protein aggregation into amyloid fibrils is associated with several amyloidoses, including neurodegenerative Alzheimer's and Parkinson's diseases. Despite years of research and numerous studies, the process is still not fully understood, which significantly impedes the search for cures of amyloid-related disorders. Recently, there has been an increase in reports of amyloidogenic protein cross-interactions during the fibril formation process, which further complicates the already intricate process of amyloid aggregation. One of these reports displayed an interaction involving Tau and prion proteins, which prompted a need for further investigation into the matter. In this work, we generated five populations of conformationally distinct prion protein amyloid fibrils and examined their interac

SUBMITTER: Ziaunys M 

PROVIDER: S-EPMC10253018 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature