Deciphering the Cardiovascular Potential of Human CD34⁺ Stem Cells.

ABSTRACT: Ex vivo monitored human CD34⁺ stem cells (SCs) injected into myocardium scar tissue have shown real benefits for the recovery of patients with myocardial infarctions. They have been used previously in clinical trials with hopeful results and are expected to be promising for cardiac regenerative medicine following severe acute myocardial infarctions. However, some debates on their potential efficacy in cardiac regenerative therapies remain to be clarified. To elucidate the levels of CD34⁺ SC implication and contribution in cardiac regeneration, better identification of the main regulators, pathways, and genes involved in their potential cardiovascular differentiation and paracrine secretion needs to be determined. We first developed a protocol thought to commit human C

SUBMITTER: Aries A 

PROVIDER: S-EPMC10253329 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature