CDNA Cloning of Feline PIWIL1 and Evaluation of Expression in the Testis of the Domestic Cat.

ABSTRACT: The PIWI clade of Argonaute proteins is essential for spermatogenesis in all species examined to date. This protein family binds specific classes of small non-coding RNAs known as PIWI-interacting RNAs (piRNAs) which together form piRNA-induced silencing complexes (piRISCs) that are recruited to specific RNA targets through sequence complementarity. These complexes facilitate gene silencing through endonuclease activity and guided recruitment of epigenetic silencing factors. PIWI proteins and piRNAs have been found to play multiple roles in the testis including the maintenance of genomic integrity through transposon silencing and facilitating the turnover of coding RNAs during spermatogenesis. In the present study, we report the first characterization of PIWIL1 in the male domestic cat, a

SUBMITTER: Stalker L 

PROVIDER: S-EPMC10253428 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature