Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha Therapy.

ABSTRACT: Targeted alpha therapy (TAT) has garnered significant interest as an innovative cancer therapy. Owing to their high energy and short range, achieving selective α-particle accumulation in target tumor cells is crucial for obtaining high potency without adverse effects. To meet this demand, we fabricated an innovative radiolabeled antibody, specifically designed to selectively deliver ²¹¹At (α-particle emitter) to the nuclei of cancer cells. The developed ²¹¹At-labeled antibody exhibited a superior effect compared to its conventional counterparts. This study paves the way for organelle-selective drug delivery.

SUBMITTER: Iizuka Y 

PROVIDER: S-EPMC10253442 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature