Vitamin D and Bone fragility in Individuals with Osteogenesis Imperfecta: A Scoping Review.

ABSTRACT: Vitamin D affects several body functions, and thus general health, due to its pleiotropic activity. It plays a key role in bone metabolism, and its deficiency impacts bone development, leading to bone fragility. In osteogenesis imperfecta (OI), a group of hereditary connective tissue disorders characterized by bone fragility, additional factors, such as vitamin D deficiency, can affect the expression of the phenotype and aggravate the disorder. The aim of this scoping review was to assess the incidence of vitamin D deficit in OI patients and the association between vitamin D status and supplementation in individuals affected by OI. We searched the PubMed Central and Embase databases and included studies published between January/2000 and October/2022 evaluating vitamin D measurement and st

SUBMITTER: Gnoli M 

PROVIDER: S-EPMC10253769 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature