Design, Pharmacological Characterization, and Molecular Docking of Minimalist Peptidomimetic Antagonists of α₄β₁ Integrin.

ABSTRACT: Integrin receptors mediate cell-cell interactions via the recognition of cell-adhesion glycoproteins, as well as via the interactions of cells with proteins of the extracellular matrix, and upon activation they transduce signals bi-directionally across the cell membrane. In the case of injury, infection, or inflammation, integrins of β₂ and α₄ families participate in the recruitment of leukocytes, a multi-step process initiated by the capturing of rolling leukocytes and terminated by their extravasation. In particular, α₄β₁ integrin is deeply involved in leukocyte firm adhesion preceding extravasation. Besides its well-known role in inflammatory diseases, α₄β₁ integrin is also involved in cancer, being expressed in various t

SUBMITTER: Baiula M 

PROVIDER: S-EPMC10253817 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature