Ontology highlight
ABSTRACT:
SUBMITTER: Zerbib A
PROVIDER: S-EPMC10253849 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Zerbib Avital A Simon Itamar I
International journal of molecular sciences 20230601 11
Origins of replication are genomic regions in which replication initiates in a bidirectional manner. Recently, a new methodology (origin-derived single-stranded DNA sequencing; ori-SSDS) was developed that allows the detection of replication initiation in a strand-specific manner. Reanalysis of the strand-specific data revealed that 18-33% of the peaks are non-symmetrical, suggesting a single direction of replication. Analysis of replication fork direction data revealed that these are origins of ...[more]